NAD (Nicotinamide Adenine Dinucleotide) history of use
Has been used since the late 1960s in intravenous form to significantly lessen withdrawal from a variety of drugs and alcohol
Mechanism not clear
Limitation is that recovery tends not to be complete with IV NAD alone
With addition of specified amino acids complex, recovery is found to be significantly more profound, complete and lasting
Primarily a universal cellular electron transporter Several recognized non-redox roles:
Important in cell nuclear DNA repair and telomere maintenanceˡ
Extracellular signaling molecule:
From neurons in blood vessels, urinary bladder², large intestine; and transcription regulation and aging via sirtuinsᶾ
Released from neurosecretory cells and brain synaptosomes⁴
Future of IV NAD
Safety – Inherently safe at doses of 2 gms/day or less Generally give 800 to 1800 mg per day, over 3-8
Treatment for 7-16 days, depending on drug history Able to address benzodiazepine dependence
Clearly the best current solution to the expanding problems of drug abuse (particularly heroin), prescription drug abuse, and post-acute withdrawal syndrome (PAWS)
1. Bürkle A (2005). “Poly(ADP-ribose). The most elaborate metabolite of NAD+.” FEBS J. 272 (18): 4576–89.
2. Smyth LM, Bobalova J, Mendoza MG, Lew C, Mutafova- Yambolieva VN (2004). “Release of beta-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder.” J Biol Chem. 279 (47): 48893–903
3. Blander G, Guarente L (2004). “The Sir2 family of protein deacetylases.” Annu. Rev. Biochem. 73: 417–35
4. Billington RA, Bruzzone S, De Flora A, Genazzani AA, Koch-Nolte F, Ziegler M, Zocchi E (2006). “Emerging functions of extracellular pyridine nucleotides.” Mol Med. 12 (11–12): 324–7.
5. Broom SL, Owen S, Norris P, Mestayer R, Grace C, Shen G, Hitt W (2008). “Amino acid-based nutritional supplementation facilitates abrupt cessation (“stopping cold turkey”) of substance use by addiction patients: Reduction of withdrawal symptoms with minimal abuse potential.” Presentation, Soc. for Neuroscience annual meeting, 19 Nov. 2008.
6. Humiston J (2014). “Treatment of Drug and Alcohol Dependence and Chronic Pain with Intravenous Amino Acids.” Meeting of the Int’l College of Integrative Medicine, Dearborn, Michigan, 25 Sept. 2014.