Synonyms

    1,4-dihydronicotinamide adenine dinucleotide
    DPNH
    NAD reduced form
    Nicotinamide adenine dinucleotide (reduced)
    Nicotinamide-adenine dinucleotide, reduced
    Reduced nicotinamide adenine diphosphate
    Reduced nicotinamide-adenine dinucleotide

    CAS number 58-68-4

    WeightAverage: 665.441

    Monoisotopic: 665.124771695

    Chemical FormulaC21H29N7O14P2

    Description

    NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5′-diphosphate coupled to adenosine 5′-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2′ position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed)

    Pharmacology

    A coenzyme composed of ribosylnicotinamide 5′-diphosphate coupled to adenosine 5′-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). The action of supplemental NADH is unclear. Oral NADH supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia. Researchers are also studying the value of NADH supplements for improving mental function in people with Alzheimer’s disease, and minimizing physical disability and relieving depression in people with Parkinson’s disease. Some healthy individuals also take NADH supplements orally to improve concentration and memory capacity, as well as to increase athletic endurance. However, to date there have been no published studies to indicate that using NADH is in any way effective or safe for these purposes.
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